Hot flashes linked to increased risk of hip fracture

oldladycaneWomen, take note: moderate to severe hot flashes and night sweats during menopause likely means lower bone mineral density and a greater chance of hip fracture than your peers without these symptoms, according to a new study.

“Our findings suggest women who exhibit moderate or severe menopausal symptoms are more likely to have issues with bone health than their peers,” said study author Carolyn J. Crandall, MD, MS, of the David Geffen School of Medicine at the University of California, Los Angeles. “This is the first large cohort study to examine the relationship between menopausal symptoms and bone health in menopausal women.”

About 60 percent of women experience hot flashes, which can last for several years.

Postmenopausal women face a greater risk of developing osteoporosis, a condition that causes bones to weaken and break more easily than do younger adults or either gender. According to the National Osteoporosis Foundation, 80 percent of the 10 million people in the U.S. with osteoporosis are women. Menopause speeds the body’s normal process of bone loss. In postmenopausal women, the body tends to breaks down old bone tissue faster than it can be replaced.

The prospective cohort study examined data from 23,573 participants in the Women’s Health Initiative (WHI) Clinical Trial. The participants were women between the ages of 50 and 79. The study, which was conducted at 40 clinical centers across the country, tracked women’s annual visits for 8 years, on average. Participants asked about their menopausal symptoms, including hot flashes and night sweats, during the initial visit. WHI participants then were monitored for fractures during the follow-up period.

Among the participants, 4,867 had their bone mineral density measured as part of a sub-study. The analysis found women who reported having moderate or severe hot flashes when they entered the study were more likely to fracture a hip during the follow-up period than women who had no menopausal symptoms. After researchers adjusted for age, body mass index and demographic factors, they found women who had moderate to severe menopausal symptoms had lower bone mass density at the neck and spine during the follow-up period than women with no symptoms.

“More research is needed to illuminate the connection between bone health and menopausal symptoms such as hot flashes,” said Crandall. “Improved understanding would help clinicians advise women on how to better prevent osteoporosis and other bone conditions. Women who have hot flashes and want to protect their bones may benefit from healthy lifestyle habits such as avoiding smoking and excessive alcohol consumption, exercising and getting sufficient calcium and vitamin D.”

The findings appear in the current issue of the Journal of Clinical Endocrinology & Metabolism.

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